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Invitrogen™ SLC4A4 Polyclonal Antibody
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Catalog No. PIPA592401
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100 μL
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Catalog No. Quantity
PIPA592401 100 μL
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Catalog No. PIPA592401 Supplier Invitrogen™ Supplier No. PA592401
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Description

Rabbit Polyclonal Antibody

Positive Samples: 293T; Cellular Location: Basolateral cell membrane, Multi-pass membrane protein Immunogen sequence: VMILALVAVR KGMDYLFSQH DLSFLDDVIP EKDKKKKEDE KKKKKKKGSL DSDNDDSDCP YSEKVPSIKI PMDIMEQQPF LSDSKPSDRE RSPTFLERHT S.

Slc4a4 encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Slc4a4 is an electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. Moreover, Slc4a4 may regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Isoform 2: May have a higher activity than isoform 1. Mutations in the Slc4a4 gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for the Slc4a4 gene. Diseases associated with SLC4A4 include Renal Tubular Acidosis, Proximal, With Ocular Abnormalities and Proximal Renal Tubular Acidosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLC4A4
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.69 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene SLC4A4
Gene Accession No. O88343, Q9JI66, Q9Y6R1
Gene Alias AI835705; Electrogenic sodium bicarbonate cotransporter 1; electrogenic sodium bicarbonate cotransporter NBCe1 variant D; hhNMC; HNBC 1; HNBC1; KNBC; kNBC 1; kNBC1; Na(+)/HCO3(-) cotransporter; Na+HCO3- cotransporter 4; NBC; NBC 1; NBC 2; NBC1; NBC2; Nbc4; NBCE 1; NBCE1; NBCe1-A; NBC-like protein; OTTHUMP00000160355; OTTHUMP00000218884; OTTHUMP00000218885; pancreas sodium bicarbonate cotransporter; PNBC; Rnbc1; SLC4A4; SLC4A5; sodium bicarbonate cotransporter; sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas); solute carrier family 4 (anion exchanger), member 4; solute carrier family 4 (sodium bicarbonate cotransporter), member 4; solute carrier family 4 member 4; solute carrier family 4, member 4; solute carrier family 4, sodium bicarbonate cotransporter, member 4; solute carrier family 4, sodium bicarbonate cotransporter, member 4, brain type; solute carrier family 4, sodium bicarbonate cotransporter, member 5
Gene Symbols SLC4A4
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 978-1078 of human SLC4A4 / NBC (NP_0010919541).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54403, 84484, 8671
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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