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Invitrogen™ SMAD2/SMAD3 Polyclonal Antibody
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Catalog No. PIPA5120657
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PIPA5120657 100 μL
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Catalog No. PIPA5120657 Supplier Invitrogen™ Supplier No. PA5120657
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Description

Rabbit Polyclonal Antibody

Positive test controls include: 293T. The target is usually found in the following locations: Cytoplasm, Nucleus. Immunogen sequence: EYAFNLKKDE VCVNPYHYQR VETPVLPPVL VPRHTEILTE LPPLDDYTHS IPENTNFPAG IEPQSNYIPE TPPPGYISED GETSDQQLNQ SMDTGSPAEL SPTTLSPVNH SLDLQPVTYS E.

Smad proteins, the mammalian homologs of the Drosophila mothers against decapentaplegic (Mad), have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1 (also designated Madr1 or JV4-1) and Smad5 are effectors of BMP-2 and BMP-4 function, while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFβ and Activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to Activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad proteins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SMAD2/SMAD3
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.32 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene SMAD2
Gene Accession No. O70436, P84022, P84025, Q15796, Q62432, Q8BUN5
Gene Alias 7120426M23Rik; AU022421; hMAD-2; hMAD-3; hSMAD2; hSMAD3; HSPC193; HsT17436; JV15-2; JV18; JV18-1; LDS1C; LDS3; MAD (mothers against decapentaplegic, Drosophila) homolog 3; MAD homolog 2; MAD homolog 3; mad homolog JV15-2; mad protein homolog; MAD, mothers against decapentaplegic homolog 3; mad3; MADH2; MADH3; MADR2; mad-related protein 2; mMad2; mMad3; mother against DPP homolog 2; mothers against decapentaplegic homolog 2; Mothers against decapentaplegic homolog 3; mothers against DPP homolog 2; mothers against DPP homolog 3; pSMAD2; Sma- and Mad-related protein 2; SMA- and MAD-related protein 3; SMAD; Smad 2; Smad 3; SMAD family member 2; SMAD family member 3; SMAD, mothers against DPP homolog 2; SMAD, mothers against DPP homolog 3; Smad2; Smad-2; Smad3
Gene Symbols SMAD2, SMAD3
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 150-270 of human SMAD2/SMAD3SMAD3 (NP_0058931).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17126, 17127, 25631, 29357, 4087, 4088
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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