SMC1A Monoclonal Antibody (OTI5A1), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA809793

Catalog No. 50-168-3026

Description

Structural Maintece of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromo proteins are conserved in eukaryotes and lead to mitotic chromosome segregatior defects. This suggests a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. Mutations in the gene can lead to Cornelia de Lange syndrome 2.

Specifications

• Antigen: SMC1A
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q14683, Q9CU62
• Gene Symbols: Smc1a
• Immunogen: Human recombit protein fragment corresponding to amino acids 889-1016 of human SMC1A produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI5A1
• Conjugate: Unconjugated
• Gene: SMC1A
• Gene Alias: CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 24061, 8243
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid