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Invitrogen™ SMC6 Polyclonal Antibody
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Catalog No. PIPA580042
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100 μg
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PIPA580042 100 μg
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Catalog No. PIPA580042 Supplier Invitrogen™ Supplier No. PA580042
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human Hela whole cell, human HepG2 whole cell, human PANC-1 whole cell, human SK-OV-3 whole cell, human COLO-320 whole cell, rat testis tissue, mouse testis tissue. IHC: rat testis tissue, human testis tissue, mouse testis tissue. ICC/IF: A431 cell. Flow: A431 cell.

Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen SMC6
Applications ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 4mg trehalose and 0.05mg sodium azide
Gene SMC6
Gene Accession No. Q924W5, Q96SB8
Gene Alias 2810489L22Rik; 3830418C19Rik; AA990493; AU018782; AW742439; hSMC6; Kiaa4103; mKIAA4103; mSMC6; SMC protein 6; Smc6; SMC-6; SMC6 structural maintenance of chromosomes 6-like 1; SMC6L1; structural maintenance of chromosomes 6; structural maintenance of chromosomes protein 6; Structural maintenance of chromosomes protein 6-like protein
Gene Symbols SMC6
Host Species Rabbit
Immunogen E. coli-derived human SMC6L1 recombinant protein (Position: D205-E443).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 313961, 67241, 79677
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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