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Invitrogen™ SMN1 Monoclonal Antibody (2B1)
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Catalog No. PIMA546549
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50 μg
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PIMA546549 50 μg
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Catalog No. PIMA546549 Supplier Invitrogen™ Supplier No. MA546549
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Description

Mouse Monoclonal Antibody

Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Western blot detects a band of approximately 42 kDa (predicted molecular weight: 35 kDa). For ICC/IF, permeabilize with 0.15% Triton.

The SMN1 gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein - survival motor neuron protein. The SMN complex plays a catalyst role in the assemble of small nuclear ribonucleoproteins, the building blocks of the spliceosome. Mutations in the SMN1 gene are known to cause spinal muscular atrophy 1/2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SMN1
Applications ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 2B1
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene SMN1
Gene Accession No. P97801, Q16637
Gene Alias AI849087; BCD541; component of gems 1; Gemin1; Gemin-1; SMA; SMA@; SMA1; SMA2; SMA3; SMA4; Smn; SMN1; SMN2; SMNC; SMNT; survival motor neuron 1; survival motor neuron 1 protein; survival motor neuron protein; survival of motor neuron 1, telomeric; survival of motor neuron protein; T-BCD541; TDRD16A; tudor domain containing 16A
Gene Symbols SMN1
Host Species Mouse
Immunogen Purified human recombinant His 6 tagged-SMN protein.
Purification Method Protein A
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20595, 6606
Target Species Human, Mouse, Frog
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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