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SMO Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501733085 Shop All Proteintech Group Inc Products
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50-173-3085 150 μL
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Catalog No. 50-173-3085 Supplier Proteintech Group Inc Supplier No. 207871AP150UL
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Description

Rabbit Polyclonal Antibody

Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 aa, seven transmembrane G protein-coupled receptors with 4 glycosylation sites and a putative extracellular amino terminus. Smoothened activated by b-Arrestin 2 and GRK2 acts as a receptor for Shh, the Sonic hedgehog gene product, and is a positive regulator of hedgehog signaling pathway along with the smoothened inhibitor patched protein (PTCH) and regulates vertebrate developmental processes, cellular proliferation and differentiation by activating transcription factor Gli. Smoothened mutants are known to cause sporadic basal cell carcinoma of the skin. It is known to express widely in heart and brain.

Specifications

Antigen SMO
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.44 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene SMO
Gene Accession No. Q99835
Gene Alias Gx, Protein Gx, SMO, SMOH, Smoothened homolog
Gene Symbols SMO
Host Species Rabbit
Immunogen SMO Fusion Protein Ag14322
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6608
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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