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Tocris Bioscience™ SN 38
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Catalog No. 268450
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Quantity:
10 mg
50 mg
Catalog No. Quantity
26-845-0 50 mg
26-841-0 10 mg
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Catalog No. 26-845-0

Supplier: Tocris Bioscience™ 2684/50

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Description

DNA topoisomerase I inhibitor; antitumor

Active metabolite of CPT-11 (Cat. No. 2688) that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).

Chemical Identifiers

CAS 86639-52-3
Molecular Formula C22H20N2O5

Specifications

Quantity 50 mg
Formula Weight 392.4
Purity >98%
Molecular Weight (g/mol) 392.411
Chemical Name or Material SN 38

Safety and Handling

Recommended Storage Store at +4°C
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