Tocris™ SN-6

Selective Na+/Ca2+ exchange inhibitor (reverse mode)

Manufacturer: Tocris™ 2184/50

 View all options for this product

Catalog No. 21-845-0

  Check Availability
Add to Cart


For Research Use Only


    Product Type SN-6
    Inhibitors SN-6
    Purity >99
    Molecular Weight 402.16
    Quantity 50mg

    Selective Na+/Ca2+-exchange (NCX) inhibitor; displays some selectivity for NCX1. IC50 values are 2.9, 16 and 8.6µM for inhibition of intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh receptors (IC50 = 18µM) but minimal activity against NCKX2 and various receptors and ion channels (IC50 > 30µM). Preferentially blocks Ca2+ influx mode and is more selective for NCX isoforms than KB-R7943 (Cat. No. 1244). Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC50 = 0.63µM).

    • Chemical Name: 2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester
    • Formula: C20H22N2O5S
    • CAS Number: 415697-08-4
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >99

  • Description & Specifications

Related Products

Product Content Feedback

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit