SNAI1 Mouse anti-Human, Clone: OTI10D7, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF500366

Catalog No. 50-165-9446

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Zinc finger protein SNAI1 (SNAIL)is a zinc finger transcriptional repressor which down regulates the expression of the ectodermal gene within the mesoderm and functions to form the mesoderm and neural crest. It is reported that SNAI1 acts as an important factor of tumor invasion as evidenced by its role in E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT). In human breast cancer, the expression of SNAI1 and/or the homologous SNAI2 (Slug) has been associated with E-cadherin repression, local or distant metastasis, tumor recurrence, or poor prognosis in different tumor series. It is also reported that Snail 1 protein in the stromamay be anew putative prognosis marker for colon tumors.

Specifications

• Antigen: SNAI1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: SNAI1
• Gene Alias: SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6615
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI10D7
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: O95863
• Gene Symbols: SNAI1
• Immunogen: Full-length protein expressed in 293T cell transfected with human SNAI1 expression vector
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1