SNAI2 Mouse anti-Human, Clone: OTI2C3, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF504933

Catalog No. 50-166-3257

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemapoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.

Specifications

• Antigen: SNAI2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: SNAI2
• Gene Alias: SLUG, SLUGH, SLUGH1, SNAIL2, WS2D
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6591
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Flow Cytometry, Western Blot
• Clone: OTI2C3
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: O43623
• Gene Symbols: SNAI2
• Immunogen: Full length human recombit protein of human SNAI2 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1