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Invitrogen™ SOCS1 Monoclonal Antibody (4H1)
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Catalog No. 374100
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100 μg
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Catalog No. Quantity
37-410-0 100 μg
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Catalog No. 37-410-0 Supplier Invitrogen™ Supplier No. 374100
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Description

Mouse Monoclonal Antibody

SOCS1 Monoclonal Antibody for Western Blot, IHC (P), ELISA, IP

The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SOCS1
Applications ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 4H1
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene Socs1
Gene Accession No. O35716
Gene Alias CIS1; Cish1; Cish7; cytokine inducible SH2-containing protein 1; cytokine inducible SH2-containing protein 7; cytokine-inducible SH2 protein 1; JAB; JAK binding protein; JAK2-binding protein; JAK-binding protein; Socs1; SOCS-1; SSI1; SSI-1; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; Suppressor of cytokine signaling 1; Tec-interacting protein 3; TIP3; TIP-3
Gene Symbols Socs1
Host Species Mouse
Immunogen Recombinant protein derived from the N-terminal region of the mouse SOCS-1 (Suppressor of Cytokine Signaling-1, also known as SSI-1) protein.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12703
Target Species Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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