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Invitrogen™ SOCS3 Monoclonal Antibody (1B2)
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Catalog No. 377200
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100 μg
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Catalog No. Quantity
37-720-0 100 μg
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Catalog No. 37-720-0 Supplier Invitrogen™ Supplier No. 377200
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Description

Mouse Monoclonal Antibody

SOCS3 Monoclonal Antibody for Western Blot, ELISA

Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SOCS3
Applications ELISA, Western Blot
Classification Monoclonal
Clone 1B2
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene Socs3
Gene Accession No. O14543, O35718
Gene Alias ATOD4; CIS3; CIS-3; Cish3; cytokine inducible SH2-containing protein 3; cytokine-inducible SH2 protein 3; E2a-Pbx1 target gene in fibroblasts 10; Ef10; EF-10; MGC71791; Protein EF-10; Socs3; Socs-3; SSI3; SSI-3; STAT-induced STAT inhibitor 3; Suppressor of cytokine signaling 3
Gene Symbols Socs3
Host Species Mouse
Immunogen Synthetic peptide derived from the N-terminal region of the mouse SOCS-3 protein.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12702, 9021
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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