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Invitrogen™ Sortilin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA118312

Catalog No. 01-670-565


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Description

Description

Reconstitute in 100 μL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Sortilin
Polyclonal
Unconjugated
Sort1
100 kDa NT receptor; 2900053A11Rik; AI852375; Glycoprotein 110; glycoprotein 95; Gp110; Gp95; LDLCQ6; mNTR3; neurotensin receptor 3; NT3; NTR3; Nts3; Ntsr3; Sort1; Sortilin; sortilin 1
Rabbit
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
ELISA, Immunohistochemistry (Frozen)
Conc. Not Determined
Whole serum with no preservative
O54861, Q6PHU5, Q99523
Sort1
Extracellular domain of glycosylated human sortilin produced in CHO cells.
RUO
20661, 6272, 83576
-20°C, Avoid Freeze/Thaw Cycles
Lyophilized
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