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SOX1 Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501733060 Shop All Proteintech Group Inc Products
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50-173-3060 150 μL
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Catalog No. 50-173-3060 Supplier Proteintech Group Inc Supplier No. 207441AP150UL
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Description

Rabbit Polyclonal Antibody

SOX1, also known as SRY (sex determining region Y)-box 1, is a transcription factor belonging to the SRY-related HMG box family of transcription factors with a HMG box DNA-binding domain. SOX1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation. This nuclear protein acts as a modulator of LINE retroposons promoter activity and is also involved in the development of the central nervous system, mainly neural and lens development. Transcriptional activator SOX1 binds directly to the HES1 promoter and suppresses HES1 transcription, thus attenuating Notch signaling. It also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling, thus potentially attenuating the WNT signaling pathway. Expression of SOX1 is seen mostly in embryonic tissues and moderately in brain.

Specifications

Antigen SOX1
Applications Western Blot
Classification Polyclonal
Concentration 0.33 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene SOX1
Gene Accession No. O00570
Gene Alias SOX1, Transcription factor SOX 1
Gene Symbols SOX1
Host Species Rabbit
Immunogen Peptide
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6656
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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