Invitrogen™ SOX1 Recombinant Rabbit Monoclonal Antibody (JJ20-40)

Catalog No.	Quantity
PIMA532447	100 μL

Catalog No. PIMA532447 Supplier Invitrogen™ Supplier No. MA532447

Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

SOX1, also known as SRY (sex determining region Y)-box 1, is a transcription factor belonging to the SRY-related HMG box family of transcription factors with a HMG box DNA-binding domain. SOX1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation. This nuclear protein acts as a modulator of LINE retroposons promoter activity and is also involved in the development of the central nervous system, mainly neural and lens development. Transcriptional activator SOX1 binds directly to the HES1 promoter and suppresses HES1 transcription, thus attenuating Notch signaling. It also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling, thus potentially attenuating the WNT signaling pathway. Expression of SOX1 is seen mostly in embryonic tissues and moderately in brain.

Specifications

• Antigen: SOX1
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Recombinant Monoclonal
• Clone: JJ20-40
• Concentration: 1.02 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4
• Gene: SOX1
• Gene Accession No.: O00570, P53783
• Gene Alias: BB176347; LOC100912302; sex determining region Y-box 1; Sox1; Sox-1; sox1.S; SRY (sex determining region Y)-box 1; SRY box 1; SRY-box 1; SRY-box 1 S homeolog; SRY-box containing gene 1; SRY-box containing protein; SRY-box transcription factor 1; SRY-related HMG-box gene 1; transcription factor SOX-1; transcription factor SOX-1-like; XELAEV_18015596mg; XlSox1; xSox1
• Gene Symbols: SOX1
• Host Species: Rabbit
• Immunogen: Recombinant protein within Human SOX1 aa 1-391.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 20664, 6656
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG