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Invitrogen™ SOX9 Polyclonal Antibody
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Catalog No. PIPA581966
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100 μL
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PIPA581966 100 μL
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Catalog No. PIPA581966 Supplier Invitrogen™ Supplier No. PA581966
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SQRTHIKTEQ LSPSHYSEQQ QHSPQQIAYS PFNLPHYSPS YPPITRSQYD YTDHQNSSSY YSHAAGQGTG LYSTFTYMNP AQRPMYTPIA DTSGVPSIPQ THSPQHWEQP VYTQLTR Highest antigen sequence indentity to the following orthologs: Rat - 96%, Mouse - 97%.

SOX9 has a role in sex determination and differentiation of Sertoli cells. It is involved in chondrogenesis and regulates the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. Translocation of this gene can cause campomelic dysplasia. SOX9 is involved in the formation of testes from the indifferent fetal gonads. It is a major molecular component of the neuron-glia switch in developing spinal cord. During normal development, SOX9 allows the prostate epithelium to outgrow into the mesenchyme and then provides basal cell support for development and maintenance of the luminal epithelium. These functions of SOX9 are subverted in prostate cancer to support tumor growth and invasion. SOX9 may direct the formation of neural crest precursors and the development of a range of neural crest derivative. It has a transcriptional regulation in melanin production in cells. Northern blot analysis shows its expression on adult testis, adult heart, and fetal brain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SOX9
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot
Classification Polyclonal
Concentration 0.10 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SOX9
Gene Accession No. P48436, Q04887
Gene Alias 2010306G03Rik; AV220920; CMD1; CMPD1; mKIAA4243; SOX 9; Sox9; SOX-9; Sox9 transcription factor; SRA1; SRXX2; SRXY10; SRY (sex determining region Y)-box 9; SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal); SRY (sex determining region Y)-box9; SRY (sex-determining region Y)-box 9 protein; SRY box 9; SRY-box 9; SRY-Box 9 ; SRY-box containing 9; SRY-box containing gene 9; SRY-box containing protein 9; SRY-box transcription factor 9; SRY-related HMG-box, gene 9; transcription activator Sox9; transcription factor SOX-9
Gene Symbols SOX9
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SOX9. Recombinant protein control fragment (Product #RP-100725).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 140586, 20682, 6662
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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