Invitrogen™ SPANXB1 Monoclonal Antibody (OTI1E11)

Catalog No.	Quantity
PIMA527454	100 μL

Catalog No. PIMA527454 Supplier Invitrogen™ Supplier No. MA527454

Description

Mouse Monoclonal Antibody

SPANXB1 Monoclonal Antibody for Western Blot, IHC (P)

Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-tail orientation with SPANX family member B2, which appears to be a duplication of the B1 locus. The SPANXB genes are unique members of this gene family, since they contain an additional 18 nt in their coding region compared to the majority of family members. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis.

Specifications

• Antigen: SPANXB1
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: OTI1E11
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: SPANXB1
• Gene Accession No.: Q9NS25
• Gene Alias: B1; cancer/testis antigen 11.2; cancer/testis antigen family 11, member 2; CT11.2; Nuclear-associated protein SPAN-Xb; nuclear-associated protein SPAN-Xf; SPANX family member B/F; SPANX family member B1; SPANX family member F1; SPANX family, member B1; SPANX family, member B2; SPANX family, member F1; SPANX family, member F2; SPANXB; SPANX-B; SPANXB1; SPANXB2; SPANXF1; SPANXF2; sperm protein associated with the nucleus on the X chromosome B/F; sperm protein associated with the nucleus on the X chromosome B1; sperm protein associated with the nucleus, X chromosome, family member B1
• Gene Symbols: SPANXB1
• Host Species: Mouse
• Immunogen: Full length human recombinant protein of SPANXB1 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 728695
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1