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Invitrogen™ SPDYA Polyclonal Antibody
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01-950-188 100 μL
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Catalog No. 01-950-188 Supplier Invitrogen™ Supplier No. PA116959
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Description

Rabbit Polyclonal Antibody

PA1-16959 is specific for the ~36 kDa Speedy/Ringo protein (isoform 2). After a longer exposure, a 31 kDa band can be detected (isoform 1). There is also a non-specific band detected at ~58 kDa.Suggested positive control: mouse testis lysate, mouse testis protein.

Speedy A, also known as SPDYA, SPDY1, Ringo3 or SPY1, is a 313 amino acid protein that localizes to the nucleus and belongs to the speedy/ringo family. Expressed at high levels in testis and at lower levels in brain, kidney, heart, bone marrow, colon, lung, liver spleen and placenta, Speedy A functions to regulate the G1/S phase transition of the cell cycle, specifically by binding to and activating Cdc2 p34, Cdk2 and p27. Additionally, Speedy A mediates cell survival during DNA damage, suggesting that Speedy A plays a role in proper cell cycle progression throughout the life of the cell. Multiple isoforms of Speedy A exist due to alternative splicing events. The gene encoding Speedy A maps to human chromosome 2, which encodes over 1,400 genes and comprises nearly 8% of the human genome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPDYA
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.1 mg/mL
Conjugate Unconjugated
Formulation Tris citrate, tris phosphate with 0.1% sodium azide; pH 7-8
Gene SPDYA
Gene Accession No. Q5IBH7, Q5MJ70, Q8R496
Gene Alias 4921517J08Rik; 4930548B21Rik; Gs4; hSpy/Ringo A; Lm23; MLZ-465; mSpy/Ringo A; protein expressed in male leptotene and zygotene spermatocytes 465; Rapid inducer of G2/M progression in oocytes A; RINGO A; RINGO3; RINGOA; SPDY1; SPDYA; spdya {ECO:0000250; speedy A; speedy A1; speedy A2; speedy homolog 1; speedy homolog A; speedy homolog A (Xenopus laevis); speedy protein A; speedy/ringo; speedy/RINGO cell cycle regulator family member A; Speedy-1; spermatogenesis related protein Gs4; spy1; UniProtKB:Q5MJ70}
Gene Symbols SPDYA
Host Species Rabbit
Immunogen A synthetic peptide made to a C-terminal region of human Speedy/Ringo (within residues 200-286).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 101123454, 192209, 245711, 70891
Target Species Human, Mouse, Rat, Sheep
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG
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