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Enzo Life Sciences Sphingosine, D-erythro (25mg). CAS: 123-78-4
Supplier: Enzo Life Sciences BMLEI1550025
Common component of cell membranes, often as phosphatidyl conjugates. Is a potent (IC50=1-3 µM) and selective inhibitor of protein kinase C. Inhibition is competitive with diacylglycerol, phorbol dibutyrate and Ca2+ and it also inhibits PKC activation by other lipids. It is active in intact cells and has been identified as an endogenous constituent in HL-60 cells, neutrophils, rat liver, and brain and mouse tissues. Other activities include inhibition of phosphatidate phosphohydrolase, Na+,K+-ATPase, CTP:phosphocholine cytidylyltransferase, calmodulin-dependent enzymes, binding of factor VII to tissue factor, binding of thyrotropin releasing hormone to its receptor and activation of EGF receptor kinase, phospholipase D and casein kinase II. Alternative name: D(+)-erythro-1,3-Dihydroxy-2-amino-4- trans-octadecene. Purity: ≥98% (TLC). Solubility: Soluble in 100% ethanol (25mg/ml warm) or DMSO (25mg/ml warm). Long Term Storage: -20°C.
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