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Invitrogen™ SPIRE2 Polyclonal Antibody
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Catalog No. PIPA559561
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100 μL
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PIPA559561 100 μL
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Catalog No. PIPA559561 Supplier Invitrogen™ Supplier No. PA559561
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SLPCILNACS GDAKSTSCIN LSVTDAGGSA QRPRPRVLLK APTLAEMEEM NTSEEEESPC GEVTLKRDRS FSEHDLAQ Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 91%.

Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPIRE2
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.9 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SPIRE2
Gene Accession No. Q8WWL2
Gene Alias BC026502; KIAA1832; Protein spire homolog 2; SPIR2; spir-2; spire actin nucleation factor 2; spire family actin nucleation factor 2; spire homolog 2; spire homolog 2 (Drosophila); spire type actin nucleation factor 2; SPIRE2; spire-type actin nucleation factor 2
Gene Symbols SPIRE2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SPIRE2. Recombinant protein control fragment (Product #RP-98594).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84501
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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