Invitrogen™ SPIRE2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA561960

Catalog No. PIPA561960

Description

Immunogen sequence: HIPVYTLGFE SPQRVSAAKT APIQRRDIFQ SLQGPQWQSV EEAFPHIYSH GCVLKDVCSE CTSFVADVVR SSRKSVDVLN TTPRRSRQTQ SLYIPNTRTL D Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 81%.

Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). [UniProt].

Specifications

• Antigen: SPIRE2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SPIRE2
• Gene Alias: BC026502; KIAA1832; Protein spire homolog 2; SPIR2; spir-2; spire actin nucleation factor 2; spire family actin nucleation factor 2; spire homolog 2; spire homolog 2 (Drosophila); spire type actin nucleation factor 2; SPIRE2; spire-type actin nucleation factor 2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84501
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8WWL2
• Gene Symbols: SPIRE2
• Immunogen: Recombinant protein corresponding to Human SPIRE2. Recombinant protein control fragment (Product #RP-98593).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov