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Invitrogen™ SPIRE2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA561960
Description
Immunogen sequence: HIPVYTLGFE SPQRVSAAKT APIQRRDIFQ SLQGPQWQSV EEAFPHIYSH GCVLKDVCSE CTSFVADVVR SSRKSVDVLN TTPRRSRQTQ SLYIPNTRTL D Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 81%.
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). [UniProt].
Specifications
SPIRE2 | |
Polyclonal | |
Unconjugated | |
SPIRE2 | |
BC026502; KIAA1832; Protein spire homolog 2; SPIR2; spir-2; spire actin nucleation factor 2; spire family actin nucleation factor 2; spire homolog 2; spire homolog 2 (Drosophila); spire type actin nucleation factor 2; SPIRE2; spire-type actin nucleation factor 2 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
84501 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin) | |
0.3 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q8WWL2 | |
SPIRE2 | |
Recombinant protein corresponding to Human SPIRE2. Recombinant protein control fragment (Product #RP-98593). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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