Tocris™ SPP 86

Potent RET inhibitor

Manufacturer: Tocris™ 5391/10

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Catalog No. 53-911-0

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For Research Use Only


    Description SPP 86
    Molecular Weight 277.32
    Purity >98
    Quantity 10mg
    Product Type SPP 86

    Potent RET inhibitor (IC50 = 8nM). Also exhibits inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. Inhibits proliferation of HCT 116 and TPC1 cells in vitro. Cell permeable.

    • Chemical Name: 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
    • Formula: C16H15N5
    • CAS Number: 1357349-91-7
    • Solubility: Soluble to 100mM in DMSO and to 20mM in ethanol
    • Purity: >98

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