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SRD5A1 Mouse anti-Human, Clone: 1D5D8, Proteintech
Mouse Monoclonal Antibody
$518.60
Specifications
| Antigen | SRD5A1 |
|---|---|
| Clone | 1D5D8 |
| Concentration | 1 mg/mL |
| Applications | Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot |
| Classification | Monoclonal |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-173-6761
|
Proteintech Group Inc
663291IG150UL |
150 μL |
Each of 1 for $518.60
|
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Description
Steroid 5alpha-Reductase is an important enzyme in androgen physiology because it catalyzes the conversion of testosterone into the more potent 5alpha-dihydro-testosterone, which mediates androgen effects on target tissues. The enzyme exists as two isoforms: type 1, which is expressed mainly in the skin; and type 2, which is expressed mainly in the prostate. In cultured human skin cells, 5alpha-Reductase 1 shows heterogeneity of protein, and has different levels of transcriptional and translational expression. 5alpha-Reductase 1 is expressed in all portions of the hair follicle, whereas 5alpha-Reductase 2 is expressed only in mesenchymal portions. In addition, 5alpha-Reductase 1 is mainly expressed in human breast carcinoma and may play a role in the in situ production and actions of the potent androgen 5alpha-dihydrotestosterone, including inhibition of cancer cell proliferation in hormone-dependent human breast carcinoma. The 5alpha-Reductase-3alpha-hydroxysteroid dehydrogenase complex is present in the human brain, suggesting that the complex may be involved in the synthesis of neuroactive steroids or the catabolism of neurotoxic steroids.Specifications
| SRD5A1 | |
| 1 mg/mL | |
| Monoclonal | |
| Liquid | |
| RUO | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| S5AR 1, SR type 1, SRD5A1, Steroid 5 alpha reductase 1 | |
| SRD5A1 | |
| IgG1 | |
| Protein G | |
| Antibody |
| 1D5D8 | |
| Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
| Unconjugated | |
| Mouse | |
| Human | |
| P18405 | |
| 6715 | |
| SRD5A1 Fusion Protein Ag23351 | |
| Primary | |
| -20°C | |
| SRD5A1 |
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