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Invitrogen™ SRGAP2C Polyclonal Antibody
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Catalog No. FEPA5144229
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100 μg
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Catalog No. Quantity
FEPA5144229 100 μg
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Catalog No. FEPA5144229 Supplier Invitrogen™ Supplier No. PA5144229
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Description

Rabbit Polyclonal Antibody

SRGAP2C Polyclonal Antibody for ICC/IF, IHC (P), ELISA

Human-specific protein that acts as a key modifier of cortical connectivity in the human brain (PubMed:22559944, PubMed:27373832, PubMed:34707291). Acts by inhibiting the functions of ancestral paralog SRGAP2/SRGAP2A, a postsynaptic protein that regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2C is unstable but is able to heterodimerize with SRGAP2/SRGAP2A, thereby reducing SRGAP2/SRGAP2A levels through proteasome-dependent degradation (PubMed:27373832, PubMed:28333212, PubMed:31822692). Inhibition of SRGAP2/SRGAP2A by SRGAP2C leads to an increase in synaptic density and protracted synaptic maturation of both excitatory and inhibitory synapses (PubMed:27373832, PubMed:34707291). Modifies cortical circuit connectivity by increasing the number of local and long-range cortical inputs received by layer 2/3 pyramidal neurons (PubMed:34707291). Also able to increase the probability of sensory-evoked responses by layer 2/3 pyramidal neurons (PubMed:34707291).
TRUSTED_SUSTAINABILITY

Specifications

Antigen SRGAP2C
Applications ELISA, Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.03% Proclin 300; pH 7.4
Gene SRGAP2C
Gene Accession No. P0DJJ0
Gene Alias SRGAP2P1
Gene Symbols SRGAP2C
Host Species Rabbit
Immunogen Recombinant Human SLIT-ROBO Rho GTPase-activating protein 2C protein (1-242AA).
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 653464
Target Species Human
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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