Invitrogen™ SSEA1 Monoclonal Antibody (MEM-158), Biotin

Catalog No.	Quantity
01-676-224	100 μg

Catalog No. 01-676-224 Supplier Invitrogen™ Supplier No. MA119490

Description

Mouse Monoclonal Antibody

This antibody reacts with CD15, a cell membrane molecule 3-fucosyl-N-acetyllactosamine (3-FAL) strongly expressed on the surface of granulocytes, monocytes, macrophages, mast cells; it is also present on Langerhans cells and some myeloid precursors cells.

CD15 (Lewis X, Le(x); stage specific embryonic antigen-1, SSEA-1) is a trisacharide determinant (3-fucosyl-N-acetyllactosamine) expressed on several glycolipids, glycoproteins and proteoglycans of various cell types, e.g. granulocytes, mast cells, monocytes, macrophages, cells of gastric mucosa, nervous system or various tumour cells. There are several variants of Lewis x, such as sialyl-Lewis x or sulphated Lewis x. Cells with high surface expression of Le(x) antigen exhibit strong self-aggregation, based on calcium-dependent Le(x)-Le(x) interaction. This process is involved for example in embryo compaction or in autoaggregation of teratocarcinoma cells. Sialyl-Le(x) and its isomer sialyl-Le(a) are ligands of selectins. CD15 expression has been extensively used to confirm diagnosis of Hodgkin's disease.

Specifications

• Antigen: SSEA1
• Applications: Flow Cytometry, Immunoprecipitation
• Classification: Monoclonal
• Clone: MEM-158
• Concentration: 1 mg/mL
• Conjugate: Biotin
• Formulation: TBS with 15mM sodium azide; pH 8
• Gene: FUT4
• Gene Accession No.: P22083
• Gene Alias: FUTIV; Lewis X; SSEA-1
• Gene Symbols: FUT4
• Host Species: Mouse
• Immunogen: Human granulocytes.
• Purification Method: Size-exclusion chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2526
• Target Species: Human
• Content And Storage: 4°C, do not freeze
• Product Type: Antibody
• Form: Liquid
• Isotype: IgM κ