Invitrogen™ SSEA1 Monoclonal Antibody (MEM-158), FITC

Catalog No.	Quantity
01-676-292	100 Tests

Catalog No. 01-676-292 Supplier Invitrogen™ Supplier No. MA119562

Description

Mouse Monoclonal Antibody

This antibody reacts with CD15, a cell membrane molecule 3-fucosyl-N-acetyllactosamine (3-FAL) strongly expressed on the surface of granulocytes, monocytes, macrophages, mast cells; it is also present on Langerhans cells and some myeloid precursors cells. This antibody will not cross-react with porcine, bovine or sheep.

CD15 (Lewis X, Le(x); stage specific embryonic antigen-1, SSEA-1) is a trisacharide determinant (3-fucosyl-N-acetyllactosamine) expressed on several glycolipids, glycoproteins and proteoglycans of various cell types, e.g. granulocytes, mast cells, monocytes, macrophages, cells of gastric mucosa, nervous system or various tumour cells. There are several variants of Lewis x, such as sialyl-Lewis x or sulphated Lewis x. Cells with high surface expression of Le(x) antigen exhibit strong self-aggregation, based on calcium-dependent Le(x)-Le(x) interaction. This process is involved for example in embryo compaction or in autoaggregation of teratocarcinoma cells. Sialyl-Le(x) and its isomer sialyl-Le(a) are ligands of selectins. CD15 expression has been extensively used to confirm diagnosis of Hodgkin's disease.

Specifications

• Antigen: SSEA1
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: MEM-158
• Conjugate: FITC
• Formulation: TBS with 0.2% BSA and 15mM sodium azide; pH 8.0
• Gene: FUT4
• Gene Accession No.: P22083
• Gene Alias: FUTIV; Lewis X; SSEA-1
• Gene Symbols: FUT4
• Host Species: Mouse
• Immunogen: Human granulocytes.
• Purification Method: Size-exclusion chromatography
• Quantity: 100 Tests
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2526
• Target Species: Human
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Product Type: Antibody
• Form: Liquid
• Isotype: IgM κ