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SSTR3 Mouse anti-Human, Clone: OTI1A1, liquid, TrueMAB™
Mouse Monoclonal Antibody
Supplier: OriGene TA812061
SDSDocumentsProduct Certifications Promotions
DescriptionExpression of Somatostatin Receptor Type 3 (SSTR3) has been reported in brain, breast, eye, gastrointestinal tract, pancreas, and thyroid. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
|SS-3-R, SS3-R, SS3R, SSR-28|
|-20° C, Avoid Freeze/Thaw Cycles|
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human SSTR3:(NOVA). The exact sequence is proprietary.|
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