Invitrogen™ SSTR3 Polyclonal Antibody

Catalog No.	Quantity
PA3110	100 μL

Catalog No. PA3110 Supplier Invitrogen™ Supplier No. PA3110

Description

Rabbit Polyclonal Antibody

PA3-110 detects the Somatostatin Receptor 3 in human samples. PA3-110 has been used successfully in Western blot, immunocytochemistry, and immunohistochemistry procedures. In Western blot analysis of SSTR3 transfected HEK-293 cells this antibody detects a ~60-70 kDa protein representing SSTR3. The PA3-110 immunogen is a synthetic peptide corresponding to residues C Q(385) E R P P S R V A(393) of human SSTR3.

Expression of Somatostatin Receptor Type 3 (SSTR3) has been reported in brain, breast, eye, gastrointestinal tract, pancreas, and thyroid. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Specifications

• Antigen: SSTR3
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: whole serum with 0.05% sodium azide
• Gene: Sstr3
• Gene Accession No.: P32745
• Gene Alias: Smstr28; Smstr3; Smstr-3; somatostatin receptor; somatostatin receptor 28; somatostatin receptor 3; somatostatin receptor subtype 3; somatostatin receptor type 3; SS3R; SS-3-R; SS3-R; SSR-28; sst3; SSTR; SSTR3
• Gene Symbols: Sstr3
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to residues C Q(385) E R P P S R V A(393) of human SSTR3.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6753
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

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