Invitrogen™ SSTR3 Polyclonal Antibody

Catalog No.	Quantity
PA3207	100 μL

Catalog No. PA3207 Supplier Invitrogen™ Supplier No. PA3207

Description

Rabbit Polyclonal Antibody

PA3-207 detects SSTR3 in rat and mouse samples. PA3-207 has successfully been used in Western blot, immunofluorescence, immunocytochemical, and immunohistochemical (paraffin) procedures. The PA3-207 immunogen is a synthetic peptide corresponding to the C-terminal amino acids T(417)AGDKASTLSHL(428) of SSTR3.

Expression of Somatostatin Receptor Type 3 (SSTR3) has been reported in brain, breast, eye, gastrointestinal tract, pancreas, and thyroid. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This 'turn-off' activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Specifications

• Antigen: SSTR3
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: Whole serum with 0.02% sodium azide
• Gene: Sstr3
• Gene Accession No.: P30935, P30936
• Gene Alias: Smstr28; Smstr3; Smstr-3; somatostatin receptor; somatostatin receptor 28; somatostatin receptor 3; somatostatin receptor subtype 3; somatostatin receptor type 3; SS3R; SS-3-R; SS3-R; SSR-28; sst3; SSTR; SSTR3
• Gene Symbols: Sstr3
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to the C-terminal amino acids T(417)AGDKASTLSHL(428) of SSTR3.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 171044, 20607
• Target Species: Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG