Invitrogen™ SSTR5 Polyclonal Antibody

Catalog No.	Quantity
PA3112	100 μL

Catalog No. PA3112 Supplier Invitrogen™ Supplier No. PA3112

Description

Rabbit Polyclonal Antibody

PA3-112 detects the Somatostatin Receptor 5 in human samples. PA3-112 has been used successfully in Western blot, immunocytochemistry, and immunohistochemistry procedures. In Western blot analysis of SSTR5 transfected HEK-293 cells this antibody detects a ~54-63 kDa protein representing SSTR5. The PA3-112 immunogen is a synthetic peptide corresponding to residues Q(344) E A T P P A H R A A A N G L M Q T S K L(364) of human SSTR5.

Somatostatin is a multifunctional protein affecting exocrine and endocrine protein secretion, neurotransmission, and neuronal modulation and regulating cell proliferation. All these functions of Somatostatin are executed through a class of GPCR protein family members called somatostatin receptor. Till date, 6 classes of somatostatin receptors have been discovered out of which SSTR5, 364A.A protein, is a receptor subtype expressed predominantly in the pituitary and hypothalamus region of brain. Studies revealed that SSTR5 contains seven transmembrane regions and undergoes homodimerization and also heterodimerizes with SSTR1. Although the specific functions of SSTR5 are still elusive, the studies indicate that it complements SSTR2 regulation of ACTH secretion. Polymorphisms in SSTR5 gene have been observed in patients with acromegaly.

Specifications

• Antigen: SSTR5
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: Whole serum with 0.05% sodium azide
• Gene: Sstr5
• Gene Accession No.: O08858, P35346
• Gene Alias: Smstr5; Somato; somatostatin receptor; somatostatin receptor 5; Somatostatin receptor subtype 5; somatostatin receptor type 5; SS5R; SS-5-R; SS5-R; sst5; Sstr5
• Gene Symbols: Sstr5
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to residues Q(344) E A T R P A H R A A A N G L M Q T S K L(364) of human SSTR5.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 20609, 6755
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

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