Invitrogen™ SSTR5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA3112

Catalog No. PA3112

Description

PA3-112 detects the Somatostatin Receptor 5 in human samples. PA3-112 has been used successfully in Western blot, immunocytochemistry, and immunohistochemistry procedures. In Western blot analysis of SSTR5 transfected HEK-293 cells this antibody detects a ~54-63 kDa protein representing SSTR5. The PA3-112 immunogen is a synthetic peptide corresponding to residues Q(344) E A T P P A H R A A A N G L M Q T S K L(364) of human SSTR5.

Somatostatin is a multifunctional protein affecting exocrine and endocrine protein secretion, neurotransmission, and neuronal modulation and regulating cell proliferation. All these functions of Somatostatin are executed through a class of GPCR protein family members called somatostatin receptor. Till date, 6 classes of somatostatin receptors have been discovered out of which SSTR5, 364A.A protein, is a receptor subtype expressed predominantly in the pituitary and hypothalamus region of brain. Studies revealed that SSTR5 contains seven transmembrane regions and undergoes homodimerization and also heterodimerizes with SSTR1. Although the specific functions of SSTR5 are still elusive, the studies indicate that it complements SSTR2 regulation of ACTH secretion. Polymorphisms in SSTR5 gene have been observed in patients with acromegaly.

Specifications

• Antigen: SSTR5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Sstr5
• Gene Alias: Smstr5; Somato; somatostatin receptor; somatostatin receptor 5; Somatostatin receptor subtype 5; somatostatin receptor type 5; SS5R; SS-5-R; SS5-R; sst5; Sstr5
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: Conc. Not Determined
• Formulation: Whole serum with 0.05% sodium azide
• Gene Accession No.: O08858, P35346
• Gene Symbols: Sstr5
• Immunogen: Synthetic peptide corresponding to residues Q(344) E A T R P A H R A A A N G L M Q T S K L(364) of human SSTR5.
• Regulatory Status: RUO
• Gene ID (Entrez): 20609, 6755
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

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