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Tocris Bioscience™ SSYA10-001
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Catalog No. 755450
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Catalog No. Quantity
75-545-0 50 mg
75-541-0 10 mg
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Catalog No. 75-545-0 Supplier Tocris Bioscience™ Supplier No. 7554/50
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Description

Potent coronavirus helicase inhibitor; also inhibits human papillomavirus E6

SSYA10-001 is a potent coronavirus helicase inhibitor (IC50 values are 0.046 μM and >3 μM for unwinding and ATPase, respectively). Inhibits SARS-CoV-2 Nsp13 helicase (IC50 = 3.5 μM), blocks dsDNA and dsRNA unwinding activities of Nsp13 (IC50 values are 5.3 μM and 5.7 μM respectively). In a SARS-CoV replicon assay SSYA10-001 inhibits (+) sense but not (-) sense RNA synthesis (EC50 = 8.95 μM). Also inhibits human papillomavirus E6 (IC50 = 10 μM)

Specifications

Chemical Name or Material 2,4-Dihydro-5-[[(2-nitrophenyl)thio]methyl]-4-(2-propen-1-yl)-3 H-1,2,4-triazole-3-thione
CAS 675104-49-1
Quantity 50 mg
Target Antiviral Compounds
Molecular Formula C12H12N4O2S2
Purity 0.98
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