Invitrogen™ STARD3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA1562

Catalog No. PA1562

Description

PA1-562 detects MLN64 from rat tissues. PA1-562 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~53 kDa protein representing MLN64 from rat adrenal gland tissue extracts. This antibody also detects an ~25 kDa protein from rat adrenal gland which may correspond to degradation product. PA1-562 antigen is recombinant MLN64 protein.

The steroidogenic acute regulatory (StAR) protein facilitates the movement of cholesterol from the outer to inner mitochondrial membrane in adrenal and gonadal cells, fostering steroid biosynthesis. MLN64 is a 445-amino acid protein of unknown function. When 218 amino-terminal residues of MLN64 are deleted, the resulting N-218 MLN64 has 37% amino acid identity with StAR and 50% of StAR's steroidogenic activity in transfected cells. Bacterially expressed N-218 MLN64 exerts StAR-like activity to promote the transfer of cholesterol from the outer to inner mitochondrial membrane in vitro. The presence of a protease-resistant domain and a protease-sensitive carboxy-terminal domain in N-218 MLN64 is similar to the organization of StAR. However, as MLN64 never enters the mitochondria, the protease-resistant domain of MLN64 cannot be a mitochondrial pause-transfer sequence, as has been proposed for StAR.

Specifications

• Antigen: STARD3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: STARD3
• Gene Alias: CAB1; Es64; metastatic lymph node gene 64 protein; metastatic lymph node protein 64; MLN 64; MLN64; Protein CAB1; Protein ES 64; protein MLN 64; StAR related lipid transfer domain containing 3; STARD3; StAR-related lipid transfer (START) domain containing 3; StAR-related lipid transfer domain containing 3; stAR-related lipid transfer protein 3; START domain containing 3; START domain-containing protein 3; steroidogenic acute regulatory protein related
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 363675
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: 0
• Gene Symbols: STARD3
• Immunogen: Recombinant MLN64 protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgG