Staurosporine, 99+%, Thermo Scientific Chemicals

Description

Staurosporine (staurosporin, CAS # 62996-74-1) is a bacterial alkyloid isolated from Streptomyces staurosporeus.

Broad spectrum protein kinase inhibitor Staurosporine is used as anti-fungal and anti-hypertensive, which results to study the anti-cancer treatment. It acts as a precursor to protein kinase inhibitor midostaurin. It is also used to induce cell death in Swiss Webster primary macrophage cells and to study the effect of caspase activation on human sperm quality.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Staurosporine is an indolocarbazole alkaloid capable of permeating cell membranes
• Staurosporine has anti-cancer properties that can induce apoptosis
• Staurosporine is a broad inhibitor of protein kinases, preventing growth and division cycles

Application

• Staurosporine is used for research on acute myeloid leukemia
• It is suitable for research applications including cell culture and biochemistry

Specifications

Chemical Identifiers

• CAS: 62996-74-1
• Molecular Formula: C28H26N4O3
• Molecular Weight (g/mol): 466.541
• MDL Number: MFCD00077402
• InChI Key: HKSZLNNOFSGOKW-ZYSRIHRCSA-N
• Synonym: Antibiotic AM-2282
• PubChem CID: 49831000
• SMILES: CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

• Type: Staurosporine
• Physical Form: Powder
• Melting Point: 240°C to 243°C
• Color: Yellow
• Quantity: 1 mg
• Beilstein: 1060573
• Merck Index: 14,8802
• Solubility Information: Soluble in DMSO or ethanol;Soluble in dimethyl sulfoxide ,dimethyl formamide,ethyl acetate,hot acetone and ethanol; Slightly soluble in chloroform and methanol; Insoluble in water.
• Formula Weight: 466.54
• Percent Purity: ≥99%
• Chemical Name or Material: Staurosporine

Safety and Handling

Hazard Category	H351
Hazard Statement	GHS H Statement H350 May cause cancer.
Precautionary Statement	P201-P202-P280-P308+P313-P501c
RTECSNumber	KD5084000
TSCA	No
storageNote1	-30° to -10°C
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only