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ATCC STC-1; Intestinal Neuroendocrine Cells; Mouse (Mus musculus)

Catalog No. 502381910
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STC-1 is an intestinal neuroendocrine cell line that was isolated in 1990 from the intestine of a 10-to-13-week-old mouse with carcinoma. The STC-1 cell line was derived from the intestinal tumors of double transgenic mice. Transgenic mice harboring a hybrid gene linking the rat insulin promoter (RIP) to polyoma small T (PyST) antigen were mated with transgenic mice harboring rat insulin promoter (RIP) linked to SV40 early region (Tag) creating off-spring harboring both transgenes (double transgenics). These mice were found to have frequent intestinal tumors in addition to pancreatic Beta-cell tumors. Gene expression studies suggested that the intestinal and pancreatic tumors arose as separate entities. The STC-1 cell line produces the hormone secretin. This cell line may be a useful model for human endocrine neoplasms of the gut. This cell line was deposited by Douglas Hanahan, PhD Cold Spring Harbor Laboratory.

Catalog No. 50-238-1910 Supplier ATCC Supplier No. CRL3254
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STC-1 is an intestinal neuroendocrine cell line that was isolated in 1990 from the intestine of a 10-to-13-week-old mouse with carcinoma. The STC-1 cell line was derived from the intestinal tumors of double transgenic mice. Transgenic mice harboring a hybrid gene linking the rat insulin promoter (RIP) to polyoma small T (PyST) antigen were mated with transgenic mice harboring rat insulin promoter (RIP) linked to SV40 early region (Tag) creating off-spring harboring both transgenes (double transgenics). These mice were found to have frequent intestinal tumors in addition to pancreatic Beta-cell tumors. Gene expression studies suggested that the intestinal and pancreatic tumors arose as separate entities. The STC-1 cell line produces the hormone secretin. This cell line may be a useful model for human endocrine neoplasms of the gut. This cell line was deposited by Douglas Hanahan, PhD Cold Spring Harbor Laboratory.

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