STRAP Polyclonal Antibody, Bethyl Laboratories

Catalog No.	Quantity
50-156-8529	20 μL

Catalog No. 50-156-8529 Supplier Bethyl Laboratories, Inc Supplier No. A304735AT

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

STRAP is a 350 amino acid MAP activator with WD-40 repeats that is localized both in the cytoplasm and the nucleus. It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.

Specifications

• Antigen: STRAP
• Applications: Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene: STRAP
• Gene Accession No.: Q9Y3F4, Q9Z1Z2
• Gene Alias: MAWD, PT-WD, UNRIP, MAP activator with WD repeats, WD-40 repeat protein PT-WD, serine-threonine kinase receptor-associated protein, unr-interacting protein
• Gene Symbols: STRAP
• Host Species: Rabbit
• Immunogen: Between 300 and 350
• Purification Method: Antigen affinity chromatography
• Quantity: 20 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 11171, 20901
• Target Species: Human, Mouse
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG