Streptozotocin, MP Biomedicals™

Description

Used in the treatment of pancreatic islet cell tumors. Streptozotocin, MP Biomedicals is a glucosamine-nitrosourea, a DNA-alkylating agent that enters cells via the GLUT2 glucose transport protein. It is used to treat malignant insulinoma and to induce Ty

Streptozocin is used to treat pancreatic islet cell tumors, including malignant insulinoma. It is also used to induce Type 1 diabetes in animals for medical research purposes.

• An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets
• Induces death of insulin-secreting cells, producing an animal model of diabetes
• Potent DNA methylating agent that induces chromosomal breakage
• Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter

Specifications

Chemical Identifiers

• CAS: 18883-66-4
• Molecular Formula: C8H15N3O7
• Molecular Weight (g/mol): 265.222
• InChI Key: ZSJLQEPLLKMAKR-UHEPRFFZSA-N
• Synonym: N-(Methylnitrosocarbamoyl)-α-D-glucosamine, Streptozocin, STZ, 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
• PubChem CID: 45357367
• IUPAC Name: 1-methyl-1-nitroso-3-[(2R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
• SMILES: CN(C(=O)NC1C(C(C(OC1O)CO)O)O)N=O

• Physical Form: Powder
• Melting Point: 121°C (decomposition) (literature)
• Extinction Coefficient: EmM (228nm): 6.36 (ethanol)
• Quantity: 100 mg
• Solubility Information: Soluble in water (50mg/mL, clear to slightly hazy, light yellow solution) and ethanol.
• Formula Weight: 265.22
• Percent Purity: ∼75% α-anomer basis, ≥97%

Safety and Handling

Recommended Storage

−20°C, desiccate, store under nitrogen