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Invitrogen™ STRO-1 Monoclonal Antibody (STRO-1), PE
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Catalog No. PIMA528636
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100 μg
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PIMA528636 100 μg
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Catalog No. PIMA528636 Supplier Invitrogen™ Supplier No. MA528636
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Description

Mouse Monoclonal Antibody

This antibody recognizes an extracellular epitope of the cell surface antigen STRO-1 expressed by bone marrow mesenchymal stromal cells and nucleated erythroid precursors, but not by committed hematopoietic progenitors.

STRO-1 is a cell surface antigen expressed by stromal elements in human bone marrow. STRO-1 binds to approximately 10% of bone marrow mononuclear cells, greater than 95% of which are nucleated erythroid precursors, but does not react with committed progenitor cells (colony-forming unit granulocyte-macrophage (CFU-GM), erythroid bursts (BFU-E), and mixed colonies (CFU-Mix). From bone marrow cells, the frequency of fibroblast colony forming cells (CFU-F) is enriched approximately 100-fold in the STRO-1-positive/Glycophorin A-negative population than in the STRO-1-positive/Glycophorin A-positive population. When plated under long-term BM culture conditions, STRO-1-positive cells generate adherent cell layers containing multiple stromal cell types, including adipocytes, smooth muscle cells, and fibroblastic elements. A STRO-1-positive enriched subset of marrow cells is capable of differentiating into multiple mesenchymal lineages including hematopoiesis-supportive stromal cells with a vascular smooth muscle-like phenotype, adipocytes, osteoblasts and chondrocytes. STRO-1 is a valuable antibody for the identification, isolation and functional characterization of human bone marrow stromal cell precursors.
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Specifications

Antigen STRO-1
Applications Flow Cytometry
Classification Monoclonal
Clone STRO-1
Concentration 0.1 mg/mL
Conjugate PE
Formulation TBS with 0.2% BSA and 15mM sodium azide; pH 8
Gene Alias STRO1
Host Species Mouse
Immunogen Human CD34 positive bone marrow cells.
Purification Method Size-exclusion chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human, Rabbit, Rat
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgM λ
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Safety and Handling

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