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  8. SU 11274, Tocris Bioscience™

SU 11274, Tocris Bioscience™

Catalog No. 410110
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Selective inhibitor of MET kinase activity

Selective inhibitor of MET tyrosine kinase activity (IC50 = 0.01 μM in vitro). Reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migration in vitro and tumor angiogenesis in vivo.

Chemical Identifiers

CAS 658084-23-2
Molecular Formula C28H30ClN5O4S
Molecular Weight (g/mol) 568.089
InChI Key FPYJSJDOHRDAMT-KQWNVCNZSA-N
Synonym met kinase inhibitor, 3z-n-3-chlorophenyl-3-3,5-dimethyl-4-4-methylpiperazin-1-yl carbonyl-1h-pyrrol-2-yl methylene-n-methyl-2-oxo-2,3-dihydro-1h-indole-5-sulfonamide, 3z-n-3-chlorophenyl-3-3,5-dimethyl-4-4-methylpiperazine-1-carbonyl-1h-pyrrol-2-yl methylidene-n-methyl-2-oxo-1h-indole-5-sulfonamide, z-n-3-chlorophenyl-3-3,5-dimethyl-4-4-methylpiperazine-1-carbonyl-1h-pyrrol-2-yl methylene-n-methyl-2-oxoindoline-5-sulfonamide, pubchem19146, d0e1qi, su-mi-2, n-3-chlorophenyl-n-methyl-3-3,5-dimethyl-4-4-methylpiperazin-1-yl carbonyl-1h-pyrrol-2-yl methylene-2-oxo-2,3-dihydro-1h-indole-5-sulfonamide, su hplc , powder
PubChem CID 9549297
IUPAC Name (3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamide
SMILES CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)C=C3C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O

Specifications

Quantity 10 mg
Formula Weight 568.09
Percent Purity >97%
Chemical Name or Material SU 11274

Safety and Handling

Recommended Storage Store at -20°C
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