Invitrogen™ SUR1 Polyclonal Antibody

Catalog No.	Quantity
PIPA518974	100 μg

Catalog No. PIPA518974 Supplier Invitrogen™ Supplier No. PA518974

Description

Goat Polyclonal Antibody

This antibody is predicted to react with canine, mouse and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies. This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.

Specifications

• Antigen: SUR1
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene: ABCC8
• Gene Accession No.: Q09428
• Gene Alias: ABC36; ABCC8; AM60008PU-N; ATP binding cassette subfamily C member 8; ATP-binding cassette sub-family C member 8; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette, subfamily C (CFTR/MRP), member 8; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; D930031B21Rik; HHF1; HI; HRINS; LOW QUALITY PROTEIN: ATP-binding cassette sub-family C member 8; MRP8; PH SUR1; PHHI; sulfonylurea receptor; sulfonylurea receptor (hyperinsulinemia); sulfonylurea receptor 1; sulfonylurea receptor subunit 1; sulphonylurea receptor 1; SUR; SUR1; SUR1 protein; SUR1delta2; TNDM2
• Gene Symbols: ABCC8
• Host Species: Goat
• Immunogen: Synthetic peptide sequence (EFDKPEKLLSRKD) corresponding to the C-terminus amino acids of ABCC8 (aa 1558-1571).
• Purification Method: Ammonium Sulfate Precipitation
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6833
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG