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Invitrogen™ SWAP70 Polyclonal Antibody
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Catalog No. 01675317
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100 μg
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Catalog No. Quantity
01-675-317 100 μg
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Catalog No. 01-675-317 Supplier Invitrogen™ Supplier No. PA141490
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Description

Rabbit Polyclonal Antibody

Suggested positive control: Daudi. Predicted to react with Bovine, Chimpanzee, Canine and Mouse.

SWAP70 is a 585 amino acid regulatory protein belonging to the pleckstrin-like family with a PH domain essential for phosphatidylinositol 3, 4, 5-trisphosphate binding. SWAP70 acts as a link between the recognition of specific switch regions and causation of a DNA break and is involved in both nuclear events and in signaling B-cell activation. As a guanine nucleotide exchange factor (GEF) it transduces signals from tyrosine kinase receptors to RAC, independent of RAS. As a multiple functional signaling protein, and a component of SWAP enzyme complex, it mediates signaling of membrane ruffling by tyrosine kinase growth factor receptors, actin cytoskeleton and cell protrusion. It is widely expressed in most tissues, mature B-cells, including those associated with mucosa-associated tissue and bronchus-associated tissue, monocytes and macrophages.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SWAP70
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% gelatin and 0.05% sodium azide
Gene SWAP70
Gene Accession No. Q9UH65
Gene Alias 70kDa; AV235546; FLJ39540; HSPC321; Kiaa0640; KIAA0640 protein; SWA-70 protein; SWAP complex protein; SWAP complex protein, 70 kDa; SWAP switching B-cell complex 70; SWAP switching B-cell complex 70kDa subunit; SWAP70; SWAP-70; SWAP-70 protein; Switch-associated protein 70
Gene Symbols SWAP70
Host Species Rabbit
Immunogen A portion of amino acids 300-350 of human SWAP-70.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23075
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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