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Invitrogen™ SWAP70 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA552350
Description
Immunogen sequence: KLEEAASRAA EEEKKRLQTQ VELQARFSTE LEREKLIRQQ MEEQVAQKSS ELEQYLQRVR ELEDMYLKLQ EALEDERQAR QDEETVRKLQ AR Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
SWAP70 is a 585 amino acid regulatory protein belonging to the pleckstrin-like family with a PH domain essential for phosphatidylinositol 3, 4, 5-trisphosphate binding. SWAP70 acts as a link between the recognition of specific switch regions and causation of a DNA break and is involved in both nuclear events and in signaling B-cell activation. As a guanine nucleotide exchange factor (GEF) it transduces signals from tyrosine kinase receptors to RAC, independent of RAS. As a multiple functional signaling protein, and a component of SWAP enzyme complex, it mediates signaling of membrane ruffling by tyrosine kinase growth factor receptors, actin cytoskeleton and cell protrusion. It is widely expressed in most tissues, mature B-cells, including those associated with mucosa-associated tissue and bronchus-associated tissue, monocytes and macrophages.
Specifications
SWAP70 | |
Polyclonal | |
Unconjugated | |
SWAP70 | |
70kDa; AV235546; FLJ39540; HSPC321; Kiaa0640; KIAA0640 protein; SWA-70 protein; SWAP complex protein; SWAP complex protein, 70 kDa; SWAP switching B-cell complex 70; SWAP switching B-cell complex 70kDa subunit; SWAP70; SWAP-70; SWAP-70 protein; Switch-associated protein 70 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
20947, 23075, 293410 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
0.1 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q6A028, Q9UH65 | |
SWAP70 | |
Recombinant protein corresponding to Human SWAP70. Recombinant protein control fragment (Product #RP-89458). | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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