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Invitrogen™ SWAP70 Polyclonal Antibody
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Catalog No. PIPA552350
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PIPA552350 100 μL
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Catalog No. PIPA552350 Supplier Invitrogen™ Supplier No. PA552350
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KLEEAASRAA EEEKKRLQTQ VELQARFSTE LEREKLIRQQ MEEQVAQKSS ELEQYLQRVR ELEDMYLKLQ EALEDERQAR QDEETVRKLQ AR Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.

SWAP70 is a 585 amino acid regulatory protein belonging to the pleckstrin-like family with a PH domain essential for phosphatidylinositol 3, 4, 5-trisphosphate binding. SWAP70 acts as a link between the recognition of specific switch regions and causation of a DNA break and is involved in both nuclear events and in signaling B-cell activation. As a guanine nucleotide exchange factor (GEF) it transduces signals from tyrosine kinase receptors to RAC, independent of RAS. As a multiple functional signaling protein, and a component of SWAP enzyme complex, it mediates signaling of membrane ruffling by tyrosine kinase growth factor receptors, actin cytoskeleton and cell protrusion. It is widely expressed in most tissues, mature B-cells, including those associated with mucosa-associated tissue and bronchus-associated tissue, monocytes and macrophages.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SWAP70
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SWAP70
Gene Accession No. Q6A028, Q9UH65
Gene Alias 70kDa; AV235546; FLJ39540; HSPC321; Kiaa0640; KIAA0640 protein; SWA-70 protein; SWAP complex protein; SWAP complex protein, 70 kDa; SWAP switching B-cell complex 70; SWAP switching B-cell complex 70kDa subunit; SWAP70; SWAP-70; SWAP-70 protein; Switch-associated protein 70
Gene Symbols SWAP70
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SWAP70. Recombinant protein control fragment (Product #RP-89458).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20947, 23075, 293410
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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