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Invitrogen™ Syk Monoclonal Antibody (SYK-01)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA119332
Description
This antibody reacts with protein tyrosine kinase p72Syk (Syk; an intracellular antigen), which is required for the transduction of signals through the B cell antigen receptor (BCR) and the high affinity IgE receptor (FcepsilonRI).
Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential druge targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer. Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.
Specifications
Syk | |
Monoclonal | |
1 mg/mL | |
PBS with 15mM sodium azide; pH 7.4 | |
P43405, P48025, Q64725 | |
Syk | |
Recombinant fragment (aa 5-360) of human Syk. | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG1 |
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry | |
SYK-01 | |
Unconjugated | |
Syk | |
DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72Syk; p72-Syk; ptk72; SP1; spleen associated tyrosine kinase; spleen tyrosine kinase; SYK; syk signaling; Sykb; tyrosine-kinase syk; tyrosine-protein kinase SYK | |
Mouse | |
Protein A | |
RUO | |
20963, 25155, 6850 | |
4°C, do not freeze | |
Liquid |
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