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Invitrogen™ Synaptophysin Polyclonal Antibody
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Catalog No. PA11043
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100 μg
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PA11043 100 μg
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Catalog No. PA11043 Supplier Invitrogen™ Supplier No. PA11043
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Description

Rabbit Polyclonal Antibody

PA1-1043 detects Synaptophysin in rat, mouse, bovine, and sheep samples. PA1-1043 has been successfully used in Western blot and immunofluorescence procedures. By Western blot, this antibody detects a ~33.8 kDa protein representing Synaptophysin in rat, mouse and bovine brain tissue as well as sheep retinas. The PA1-1043 immunogen is a synthetic peptide corresponding to residues G(253) P G G Y G P Q D S Y G P Q G G Y Q P D(272) of rat Synaptophysin. This sequence is conserved in many species including human, mouse and bovine. The PA1-1043 immunizing peptide (Cat. # PEP-279) is available for use in neutralization and control experiments.

Synaptophysin is a calcium-binding and integral membrane glycoprotein present in presynaptic vesicles in almost all neurons. Synaptophysin has four transmembrane domains and it forms a complex with dynamin at high calcium concentrations suggesting an involvement in synaptic vesicle endocytosis. It is also involved in the regulation of short-term and long-term synaptic plasticity. Synaptophysin is currently the most widely used marker for nerve terminals and for differentiating neuroendocrine tumors. Mutations in the gene can result in mental retardation, X-linked 96.
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Specifications

Antigen Synaptophysin
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Syp
Gene Accession No. P07825, P08247, P20488, Q62277
Gene Alias A230093K24Rik; AI848995; BM89 antigen; I79_012252; Major synaptic vesicle protein p38; MRX96; MRXSYP; p38; Syn; Synaptophysin; Syp; Syp I; Syp1
Gene Symbols Syp
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues G(253) P G G Y G P Q D S Y G P Q G G Y Q P D(272) of rat Synaptophysin.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 101112034, 20977, 24804, 280937, 6855
Target Species Human, Mouse, Rat, Bovine, Sheep
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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