Invitrogen™ SYNPO2L Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596246

Catalog No. PIPA596246

Description

Immunogen sequence: HVTPKTPPPM APKTPPPMTP KTPPPVAPKP PSRGLLDGLV NGAASSAGIP EPPRLQGRGG ELFAKRQSRA DRYVVEGTPG PGLGPRPRSP SPTPSLPPSW K; Positive Samples: Mouse heart; Cellular Location: Cytoplasm, cytoskeleton.

SYNPO2L was initially identified as a novel heart-enriched gene that encodes a cytoskeletal protein highly expressed in the Z-disc of heart and skeletal muscle, associates with actin and interacts with a-actinin. It is a member of the synaptopodin family, sharing greatest homology with Synaptopodin 2. Recent studies have shown that SYNPO2L, while primarily localized to the sarcomere, can also translocate to the nucleus. A knockdown of SYNPO2L in zebrafish resulted in aberrant cardiac and skeletal muscle development and function, suggesting that it is a critical component of the sarcomere and plays an important role in muscle development.

Specifications

• Antigen: SYNPO2L
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SYNPO2L
• Gene Alias: 1110054M18Rik; Chap; RGD1565434; synaptopodin 2 like; synaptopodin 2-like; synaptopodin 2-like protein; SYNPO2L
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 68760
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.03 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q8BWB1
• Gene Symbols: SYNPO2L
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 700-800 of human SYNPO2L (NP_0011076051).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG