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Tocris Bioscience™ SZL P1-41
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Catalog No. 507610RD
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10 mg
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Catalog No.
50-761-0RD 10 mg
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Catalog No. 50-761-0RD Supplier Tocris Bioscience™ Supplier No. 5076/10

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Description

Selective Skp2 inhibitor

SZL P1-41 is a Skp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines.

Specifications

Chemical Name or Material 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one
CAS 222716-34-9
Quantity 10 mg
Molecular Formula C24H24N2O3S
Formula Weight 420.52
Purity 98%
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