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T-bet Monoclonal Antibody (eBio4B10 (4B10)), Alexa Fluor™ 488, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

$441.00

Specifications

Antigen T-bet
Clone eBio4B10 (4B10)
Concentration 0.5 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
53-582-582
Encompass_Preferred
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Invitrogen™
53582582
100 μg
Each of 1 for $441.00
Only null left
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Description

Description

Description: The eBio4B10 monoclonal antibody reacts with mouse, rhesus moneky and human T-bet. T-bet is a Th1-specific T-box transcription factor critical to the development of the Th1 CD4+ T cell lineage. This is known based on the observations that T-Bet deficient mice have impaired Th1 cell development, and that ectopic expression of T-Bet results in development skewed to the Th1 lineage. T-Bet expression is induced by the Th1 cytokine IFN gamma, and T-Bet also regulates the expression of IFN gamma, likely, at least in part, through the modification of DNA accessibility and histone remodeling. In addition to IFN gamma, T-Bet is also known to regulate the expression of IL-12R beta and IL-2. Moreover, T-Bet plays a role in class-switch recombination in B-cells. Applications Reported: This eBio4B10 antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This eBio4B10 antibody has been tested by intracellular staining followed by flow cytometric analysis of normal human peripheral blood cells using the Foxp3/Transcription Factor Staining Buffer Set (Product No. 00-5523-00) and protocol. Please refer to Staining Intracellular Antigens for Flow Cytometry, Protocol B: One step protocol for intracellular (nuclear) proteins located at thermofisher.com/flowprotocols. This may be used at less than or equal to 0.25 μg per test.

T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
Specifications

Specifications

T-bet
0.5 mg/mL
Monoclonal
Liquid
RUO
Q9JKD8, Q9UL17
IgG1 κ
Antibody
eBio4B10 (4B10)
Flow Cytometry
Alexa Fluor 488
Mouse
Human, Mouse, Rhesus Macaque
30009, 57765, 694044
Primary
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SDS
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Documents

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