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Invitrogen™ TAB1 Polyclonal Antibody
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Catalog No. PIPA5116001
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PIPA5116001 100 μL
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Catalog No. PIPA5116001 Supplier Invitrogen™ Supplier No. PA5116001
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total TAB1.

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. It can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TAB1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene TAB1
Gene Accession No. Q15750, Q8CF89
Gene Alias 2310012M03Rik; 3'-Tab1; b2b449Clo; beta activated kinase-1 binding protein-1; MAP3K7IP1; MGC57664; mitogen activated protein kinase kinase kinase 7 interacting protein 1; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; mitogen-activated protein kinase kinase kinase 7-interacting protein 1; RP3-407F17.2; TAB1; TAB1beta; TAK1-binding protein 1; TGF-beta activated kinase 1/MAP3K7 binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TGF-beta-activated kinase 1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1
Gene Symbols TAB1
Host Species Rabbit
Immunogen A synthesized peptide derived from human TAB1(Accession Q15750), corresponding to amino acid residues P412-F462.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10454, 315139, 66513
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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