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Invitrogen™ TAB182 Polyclonal Antibody
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Catalog No. PIPA558171
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100 μL
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PIPA558171 100 μL
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Catalog No. PIPA558171 Supplier Invitrogen™ Supplier No. PA558171
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DWTPDLGLRN MAPGAVCSPG ESKELGVGQM DWGNNLGLRD LEVTCDPDSG GSQGLRGCGV GQMDWTQDLA PQNVELFGAP SEARE Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 76%.

TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TAB182
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TNKS1BP1
Gene Accession No. Q9C0C2
Gene Alias 182 kDa tankyrase-1-binding protein; KIAA1741; TAB182; tankyrase 1 binding protein 1; tankyrase 1 binding protein 1, 182kDa; tankyrase 1-binding protein of 182 kDa; testis secretory sperm-binding protein Li 206a; TNKS1BP1
Gene Symbols TNKS1BP1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TAB182. Recombinant protein control fragment (Product #RP-97362).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 85456
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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