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Invitrogen™ TAB2 Monoclonal Antibody (G.188.0)
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Catalog No. PIMA514818
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100 μL
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PIMA514818 100 μL
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Catalog No. PIMA514818 Supplier Invitrogen™ Supplier No. MA514818
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Description

Rabbit Monoclonal Antibody

It is not recommended to aliquot this antibody.

TAB2 is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutively interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TAB2
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone G.188.0
Conjugate Unconjugated
Formulation 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
Gene Tab2
Gene Accession No. Q5U303, Q99K90, Q9NYJ8
Gene Alias 1110030N06Rik; A530078N03Rik; CHTD2; FLJ21885; KIAA0733; MAP3K7IP2; mitogen activated protein kinase kinase kinase 7 interacting protein 2; mitogen-activated protein kinase kinase kinase 7 interacting protein 2; mitogen-activated protein kinase kinase kinase 7-interacting protein 2; mKIAA0733; OTTHUMP00000017388; Tab2; TAB-2; Tak1 binding protein 2; TAK1-binding protein 2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2; TGF-beta activated kinase 1/MAP3K7 binding protein 2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2
Gene Symbols Tab2
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues surrounding Leu330 of human TAB2.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23118, 308267, 68652
Target Species Human, Mouse, Rat, Monkey
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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