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Invitrogen™ TACR3 Polyclonal Antibody
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Catalog No. PIPA534248
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50 μg
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PIPA534248 50 μg
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Catalog No. PIPA534248 Supplier Invitrogen™ Supplier No. PA534248
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Description

Rabbit Polyclonal Antibody

Percent identity with other species by BLAST analysis: Human, Gorilla (100%) Gibbon, Monkey (95%).

The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TACR3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene Tacr3
Gene Accession No. P29371
Gene Alias G protein-coupled receptor; HH11; neurokinin 3 receptor; Neurokinin B; neurokinin B receptor; neurokinin beta receptor; neuromedin K receptor; Neuromedin K receptor (Neurokinin B/Tachikin 3); neuromedin-K receptor; Nk3 receptor; NK-3 receptor; NK3R; NK-3R; NK3R TAC3R; Nkr; Nmkr; Nmk-r; TAC3R; TAC3RL; tachikin receptor 3; tachykinin receptor 3; Tacr3
Gene Symbols Tacr3
Host Species Rabbit
Immunogen Synthetic 20 amino acid peptide from N-terminal extracellular domain of human TACR3.
Purification Method Antigen affinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6870
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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